Formation of microporous poly(hydroxybutyric acid) membranes for culture of osteoblast and fibroblast
學年 98
學期 1
出版（發表）日期 2009-12-01
作品名稱 Formation of microporous poly(hydroxybutyric acid) membranes for culture of osteoblast and fibroblast
作品名稱（其他語言）
著者 Huag, Han-Shiang; Chou, Shiu-Huey; Don, Trong-Ming; Lai, Wei-Chi; Cheng, Liao-Ping
單位 淡江大學化學工程與材料工程學系
出版者 Chichester: John Wiley & Sons Ltd.
著錄名稱、卷期、頁數 Polymers for Advanced Technologies 20(12), pp.1082-1090
摘要 Microporous membranes of a biodegradable polymer, poly(hydroxybutyric acid) (PHB), were prepared by a phase-inversion process and their cell compatibility was evaluated in vitro. A ternary system, ethanol/chloroform/PHB, was employed to prepare the membranes, wherein ethanol and chloroform were served as the nonsolvent and solvent for PHB, respectively. In the phase-inversion process, the polymer dissolution temperature was varied from 80 to 120°C to yield membranes with specific morphologies, such as globular particles, porous channels, etc. Moreover, cell viability was examined on the formed membranes. Two cell lines, osteoblast hFOB1.19 and fibroblast L929, were cultured in vitro. It was found that these two types of cells exhibited different responses on different membranes: the hFOB1.19 cells showed significant increase in cell proliferation with increase in surface roughness, whereas the L929 cells demonstrated an opposite trend, preferring to attach and grow on a flat surface. PHB membranes with different morphologies exhibit different cell compatibilities, which may be useful means for the architectural design of materials for tissue engineering.
關鍵字 microporous membrane; poly(hydroxybutyric acid); hFOB1.19 cell; L929 cell
語言 en
ISSN 1099-1581
期刊性質 國外
收錄於 SCI EI
產學合作
通訊作者 Cheng, Liao-Ping
審稿制度
國別 GBR
公開徵稿
出版型式 電子版
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