The effect of turbulent viscous shear stress on red blood cell hemolysis
學年 102
學期 2
出版（發表）日期 2014-03-12
作品名稱 The effect of turbulent viscous shear stress on red blood cell hemolysis
作品名稱（其他語言）
著者 Chern, ming-Kai; Lu, Po-chien
單位 淡江大學水資源及環境工程學系 淡江大學化學學系
出版者 Tokyo: Springer Japan KK
著錄名稱、卷期、頁數 Journal of Artificial Organs 17(2),　p.178-185
摘要 Non-physiologic turbulent flow occurs in medical cardiovascular devices resulting in hemodynamic stresses that may damage red blood cells (RBC) and cause hemolysis. Hemolysis was previously thought to result from Reynolds shear stress (RSS) in turbulent flows. A more recent hypothesis suggests that turbulent viscous shear stresses (TVSS) at spatial scales similar in size to RBCs are related to their damage. We applied two-dimensional digital particle image velocimetry to measure the flow field of a free-submerged axisymmetric jet that was utilized to hemolyze porcine RBCs in selected locations. Assuming a dynamic equilibrium for the sub-grid scale (SGS) energy flux between the resolved and the sub-grid scales, the SGS energy flux was calculated from the strain rate tensor computed from the resolved velocity fields. The SGS stress was determined by the Smagorinsky model, from which the turbulence dissipation rate and then TVSS were estimated. Our results showed the hemolytic threshold of the Reynolds stresses was up to 517 Pa, and the TVSSs were at least an order of magnitude less than the RSS. The results provide further insight into the relationship between turbulence and RBC damage.
關鍵字 Hemolysis;Sub-grid scale;Turbulent dissipation rate;Viscous dissipative stresses;Particle image velocimetry
語言 en_US
ISSN 1434-7229
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 盧博堅
審稿制度 是
國別 JPN
公開徵稿
出版型式 ,紙本
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/99722 )

機構典藏連結
SDGS 良好健康和福祉