Protective Role of Comfrey Leave Extracts on UV-induced Zebrafish Fin Damage
學年 102
學期 2
出版（發表）日期 2014-07-01
作品名稱 Protective Role of Comfrey Leave Extracts on UV-induced Zebrafish Fin Damage
作品名稱（其他語言）
著者 Cheng, Chien-Chung; Chou, Chi-Yuan; Chang, Yao-Chin; Wang, Hsuan-Wen; Wen, Chi-Chung; Chen, Yau-Hung
單位 淡江大學數學學系; 淡江大學化學學系
出版者 Tokyo: Japanese Society of Toxicologic Pathology
著錄名稱、卷期、頁數 Journal of Toxicologic Pathology 27(2), pp.115-121
摘要 In zebrafish, UV exposure leads to fin malformation phenotypes including fin reduction or absence. The present study evaluated UV-protective activities of comfrey leaves extracts in a zebrafish model by recording fin morphological changes. Chemopreventive effects of comfrey leave extracts were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. The results showed that (1) the mean times of return to normal fin in the UV+comfrey (50 and 100 ppm) groups were 3.43 and 2.86 days and were quicker compared with that in the UV only group (4.21 days); (2) zebrafish fins in the UV+comfrey (50 and 100 ppm) groups were 2.05 and 3.25 times more likely to return to normal than those in the UV only group; and (3) comfrey leave extracts had UV-absorbance abilities and significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, comfrey leaves extracts may have the potential to be developed as UV-protective agents to protect zebrafish embryos from UV-induced damage.
關鍵字 comfrey;fin;UV;zebrafish
語言 en
ISSN 0914-9198
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Cheng, Chien-Chung; Chen, Yau-Hung
審稿制度 是
國別 JPN
公開徵稿
出版型式 ,紙本
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