Comparative analysis of 3D-culture system for murine neonatal heart regeneration: a systematic approach for big gene expression data
學年 102
學期 2
發表日期 2014-05-13
作品名稱 Comparative analysis of 3D-culture system for murine neonatal heart regeneration: a systematic approach for big gene expression data
作品名稱（其他語言）
著者 Weng, Julia Tzu-Ya; Chen, Yi-Cheng; Chang, Pei-Chann; Huang, Shin-Ping; Chiu, Yu-Wei
作品所屬單位 淡江大學資訊工程學系
出版者 Springner
會議名稱 The 1st International Workshop on Pattern Mining and Application of Big Data (BigPMA 2014) (in conjunction with PAKDD 2014)
會議地點 Tainan, Taiwan
摘要 Cardiovascular diseases are the leading cause of death worldwide. Loss or dysfunction of cardiomyocytes is associated with many forms of heart disease. The adult mammalian heart has a limited regenerative ability after damage, leading to the formation of fibrotic scar tissues, hypertrophy, contractile dysfunction and ul-timately, organ failure. In contrast, neonatal mammalian cardiomyocytes retain a significant replenishing potential briefly after birth. There is increasing enthusiasm to grow neonatal cardiomyocytes in 3D culture systems to artificially restore heart function. Various scaffolds and matrices are available, but the molecular and cellu-lar mechanisms underlying proliferation and differentiation of neonatal mammalian cardiomyocytes are not very well understood. Here, we utilize a systematic strategy to analyze the extensive genome-scale gene expression profiles of two different 3D constructs. We present a comprehensive comparison that may help improve the protocols for growing cardiomyocytes in a 3D culture system.
關鍵字 cardiomyocytes;regeneration;3-D culture system;gene expression;bioinformatics
語言 en_US
收錄於 EI
會議性質 國際
校內研討會地點 無
研討會時間 20140513~20140516
通訊作者 Weng, Julia Tzu-Ya
國別 TWN
公開徵稿 Y
出版型式 電子版
出處 Lecture Notes in Artificial Intelligence 8643, pp.754-764
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