Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure
學年 102
學期 2
出版（發表）日期 2014-07-21
作品名稱 Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure
作品名稱（其他語言）
著者 Lee, Kuei-Fang; Weng, Julia Tzu-Ya; Hsu, Paul Wei-Che; Chi, Yu-Hsiang; Chen, Ching-Kai; Liu, Ingrid Y.; Chen, Yi-Cheng; Wu, Lawrence Shih-Hsin
單位 淡江大學資訊工程學系
出版者 New York: Hindawi Publishing Corporation
著錄名稱、卷期、頁數 BioMed Research International 2014, 834087(9 pages)
摘要 Though damage caused by radiation has been the focus of rigorous research, the mechanisms through which radiation exerts harmful effects on cells are complex and not well-understood. In particular, the influence of low dose radiation exposure on the regulation of genes and pathways remains unclear. In an attempt to investigate the molecular alterations induced by varying doses of radiation, a genome-wide expression analysis was conducted. Peripheral blood mononuclear cells were collected from five participants and each sample was subjected to 0.5 Gy, 1 Gy, 2.5 Gy, and 5 Gy of cobalt 60 radiation, followed by array-based expression profiling. Gene set enrichment analysis indicated that the immune system and cancer development pathways appeared to be the major affected targets by radiation exposure. Therefore, 1 Gy radioactive exposure seemed to be a critical threshold dosage. In fact, after 1 Gy radiation exposure, expression levels of several genes including FADD, TNFRSF10B, TNFRSF8, TNFRSF10A, TNFSF10, TNFSF8, CASP1, and CASP4 that are associated with carcinogenesis and metabolic disorders showed significant alterations. Our results suggest that exposure to low-dose radiation may elicit changes in metabolic and immune pathways, potentially increasing the risk of immune dysfunctions and metabolic disorders.
關鍵字
語言 en_US
ISSN 2314-6141
期刊性質 國外
收錄於 SCI EI
產學合作
通訊作者 Lee, Kuei-Fang
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版,紙本
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