| Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction | |
|---|---|
| 學年 | 102 |
| 學期 | 2 |
| 出版（發表）日期 | 2014-03-04 |
| 作品名稱 | Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction |
| 作品名稱（其他語言） | |
| 著者 | Lian, Ru-Ching; Lin, Meng-Hsuan; Liao, Pin-Hsuan; Fu, Jia-Jie; Wu, Meng-Ju; Wu, Yang-Chang; Chang, Fang-Rong; Wu, Chin-Chung; Pan, Po-Shen |
| 單位 | 淡江大學化學學系 |
| 出版者 | Kidlington: Pergamon Press |
| 著錄名稱、卷期、頁數 | Tetrahedron 70(9), pp.1800–1804 |
| 摘要 | A four-component Ugi reaction (Ugi-4CR) utilizing formylphenyl boronic acids under mild condition was developed for the synthesis of arylboronic acid analogs. The reactions were performed in methanol and accelerated by microwave irradiation, which makes this strategy suitable for constructing boronic-containing chemical libraries. Two of the synthesized analogs were found to have cytotoxic activity against HepG2, MDA-MB231, and A549 cancer cell lines, demonstrating the potential application of this approach in developing novel boron-containing pharmaceuticals. |
| 關鍵字 | |
| 語言 | en |
| ISSN | 0040-4020 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Pan, Po-Shen |
| 審稿制度 | 是 |
| 國別 | GBR |
| 公開徵稿 | |
| 出版型式 | ,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/98496 ) |
| SDGS | 良好健康和福祉 |
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