Systematic Pipeline analyzing microRNA-gene interactions that may differentiate between active and latent TB infection
學年 102
學期 2
發表日期 2014-04-11
作品名稱 Systematic Pipeline analyzing microRNA-gene interactions that may differentiate between active and latent TB infection
作品名稱（其他語言）
著者 Weng, Julia T.Y.; Huang, Kai-Yao; Lee, Shih-Wei; Wu, Lawrence Shih-Hsin; Chen, Yi-Cheng; Lee, Tzong-Yi
作品所屬單位 淡江大學資訊工程學系
出版者
會議名稱 The 2014 IEEE International Symposium on Bioelectronics and Bioinformatics (ISBB 2014)
會議地點 桃園縣, 臺灣
摘要 Tuberculosis (TB) is the second most common cause of death from infectious diseases. About 90% of those infected are asymptomatic—the so-called latent TB infections (LTBI), with a 10% lifetime chance of progressing to active TB. Several gene expression studies have compared healthy controls versus active TB or LTBI patients. The results vary due to diverse genetic background, study designs, and the inherent complexity of the disease process. Thus, developing a sensitive and efficient method for the detection of LTBI is both crucial and challenging. Our objective was to establish an efficient and costeffective pipeline for gene and microRNA expression profiling in TB and LTBI. We attempted to investigate the interaction between these two types of molecular signatures as biomarkers for a more sensitive and specific differentiation among active TB, LTBI, and healthy individuals. Following our systematic pipeline, we have uncovered novel differences specific to the Taiwanese population. Differentially expressed microRNAs and their interactions with the corresponding target genes will serve as potential molecular signatures to enhance our understanding of the underlying mechanisms of TB and facilitate the development for a more sensitive diagnostic assay for LTBI.
關鍵字 tuberculosis;latent infection;microRNA;gene expression
語言 en
收錄於
會議性質 國際
校內研討會地點
研討會時間 20140411~20140414
通訊作者
國別 TWN
公開徵稿 Y
出版型式 紙本
出處 The 2014 IEEE International Symposium on Bioelectronics and Bioinformatics (ISBB 2014), 4p.
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