教師資料查詢 | 類別: 會議論文 | 教師: 陳以錚 YI-CHENG CHEN (瀏覽個人網頁)

標題:Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis
學年
學期
發表日期2014/04/11
作品名稱Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis
作品名稱(其他語言)
著者Weng, Julia T.Y.; Chen, Yi-Cheng; Ma, Chung-Hsien; Lai, Tzung-Shian; Ho, Feng-Ming
作品所屬單位淡江大學資訊工程學系
出版者
會議名稱The 2014 IEEE International Symposium on Bioelectronics and Bioinformatics (ISBB 2014)
會議地點桃園縣, 臺灣
摘要Diabetes is a debilitating metabolic disorder resulting from hyperglycemia and glucose intolerance. High glucose-induced endothelial dysfunction is an important contributor to vascular disease in diabetes. In this study, we profiled the global gene expression changes in human umbilical vein endothelial cells treated with high glucose at the 0-, 24-, and 48-hour intervals. Differentially expressed genes were examined through bioinformatics analysis for potential mechanisms of regulation. Our analysis uncovered novel regulatory interactions that may provide insights into the molecular transition from normal cellular activities to apoptosis under high glucose, enhancing our understanding of the mechanisms underlying vascular complications in diabetic patients.
關鍵字high glucose;gene expression;diabetes;timecourse analysis
語言英文
收錄於
會議性質國際
校內研討會地點
研討會時間20140411~20140414
通訊作者
國別中華民國
公開徵稿Y
出版型式紙本
出處The 2014 IEEE International Symposium on Bioelectronics and Bioinformatics (ISBB 2014), 4p.
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