Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis
學年 102
學期 2
發表日期 2014-04-11
作品名稱 Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis
作品名稱（其他語言）
著者 Weng, Julia T.Y.; Chen, Yi-Cheng; Ma, Chung-Hsien; Lai, Tzung-Shian; Ho, Feng-Ming
作品所屬單位 淡江大學資訊工程學系
出版者
會議名稱 The 2014 IEEE International Symposium on Bioelectronics and Bioinformatics (ISBB 2014)
會議地點 桃園縣, 臺灣
摘要 Diabetes is a debilitating metabolic disorder resulting from hyperglycemia and glucose intolerance. High glucose-induced endothelial dysfunction is an important contributor to vascular disease in diabetes. In this study, we profiled the global gene expression changes in human umbilical vein endothelial cells treated with high glucose at the 0-, 24-, and 48-hour intervals. Differentially expressed genes were examined through bioinformatics analysis for potential mechanisms of regulation. Our analysis uncovered novel regulatory interactions that may provide insights into the molecular transition from normal cellular activities to apoptosis under high glucose, enhancing our understanding of the mechanisms underlying vascular complications in diabetic patients.
關鍵字 high glucose;gene expression;diabetes;timecourse analysis
語言 en
收錄於
會議性質 國際
校內研討會地點
研討會時間 20140411~20140414
通訊作者
國別 TWN
公開徵稿 Y
出版型式 紙本
出處 The 2014 IEEE International Symposium on Bioelectronics and Bioinformatics (ISBB 2014), 4p.
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