Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae
學年 101
學期 1
出版（發表）日期 2012-09-01
作品名稱 Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae
作品名稱（其他語言）
著者 Chen, Y.H.; Yang, Z.S.; Wen, C.C.; Chang, Y.S.; Wang, P.C.; Hsiao, C.A.; Shih, T.Z.
單位 淡江大學數學學系暨研究所
出版者 Amsterdam: Elsevier BV
著錄名稱、卷期、頁數 Food Chemistry 134(2), pp.717-24
摘要 The antioxidant ability of an array of commercially available flavonoids was evaluated on the larvae of the zebrafish model organism, in order to find flavonoids with lower toxicities and higher radical oxygen-scavenging properties than flavone. Among the flavonoids tested, chrysin and morin possessed higher reactive oxygen species (ROS)-scavenging rates (-99% and -101%, respectively) and lower toxicity (LD(50)>100 ppm). Zebrafish fins in the UVB+chrysin group were 6.30 times more likely to grow to normal fin size than those in the UVB-only control group, while zebrafish fins in the UVB+morin group were 11.9 times more likely to grow to normal fin size than those in the UVB-only control group. These results were analysed by the QSAR method and were in accordance with predicted values. A new 4'-fluoroflavone was synthesised. The ROS-scavenging rate of 4'-fluoroflavone was -54%, which corresponds well with the predicted value (-48%). We propose that a combination of QSAR prediction and the zebrafish model organism is efficient for evaluating new flavonoids.
關鍵字
語言 en_US
ISSN 0308-8146 1873-7072
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 NLD
公開徵稿
出版型式 電子版 紙本
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/97754 )

機構典藏連結