Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model
學年 102
學期 1
出版（發表）日期 2014-01-01
作品名稱 Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model
作品名稱（其他語言）
著者 Lee, Ya-Ting; Fong, Tsorng-Harn; Chen, Hui-Min; Chang, Chao-Yuan; Wang, Yun-Hsin; Chern, Ching-Yuh; Chen, Yau-Hung
單位 淡江大學化學學系
出版者 Basel: M D P I AG
著錄名稱、卷期、頁數 Molecules 19, pp.641-650
摘要 The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. Results showed that embryos treated with 3'-hydroxychalcone 
 (compound 1b) displayed a high percentage of muscle defects (96.6%), especially myofibril misalignment. Ultrastructural analysis revealed that compound 1b-treated embryos displayed many muscle defect phenotypes, including breakage and collapse of myofibrils, reduced cell numbers, and disorganized thick (myosin) and thin (actin) filaments. Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on developing zebrafish embryos.
關鍵字 chalcone; embryogenesis; muscle; toxicity; zebrafish
語言 en_US
ISSN 1420-3049
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 CHE
公開徵稿
出版型式 電子版
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