Synthesis and Characterization of Chitosan membrane Selectively Crosslinked by Poly(ethylene glycol) Dimethacrylate
學年 102
學期 1
發表日期 2013-10-04
作品名稱 Synthesis and Characterization of Chitosan membrane Selectively Crosslinked by Poly(ethylene glycol) Dimethacrylate
作品名稱（其他語言）
著者 Cheng, Chia-Chu; Mi, Fwu-Long; Don, Trong-Ming
作品所屬單位 淡江大學化學工程與材料工程學系
出版者
會議名稱 10th International Conference of the Asian Pacific Chitin Chitosan Symposium (10th APCCS)
會議地點 Yonago, Japan
摘要 In this study, poly(ethylene glycol) dimethacrylate (PEGDMA) was used to crosslink chitosan (CS) chains selectively at the C-6 position of pyranose. Before the crosslinking reaction, the amino group at the C-2 position was protected by reaction with phthalic anhydride (PA) to form phthaloylated chitosan (PACS). From the results of elemental analysis, the degree of substitution was calculated to be 0.88, indicating most amino groups were converted to phthalimide groups. Subsequently, 3-isopropenyl-α,α-dimethylbenzyl isocyanate (TMI), a vinyl compound containing an isocyanate group, was used to react with the PACS, preferentially with the hydroxyl group at the C-6 position. The reaction with TMI thus provided multiple double bonds along the CS chain. The phthalimide group was then reduced to the original amino group by the hydrazine solution at 80oC. Finally, the vinyl CS was crosslinked with PEGDMA at the C-6 position by a UV-initiated free-radical polymerization. FTIR and NMR were used to analyze the chemical structure of PEG-crosslinked CS. Thermal and mechanical properties of the PEG-crosslinked CS membrane were measured and related to their structures. The PEGDMA-crosslinked CS membrane has potential applications as a biomedical material.
關鍵字
語言 en
收錄於
會議性質 國際
校內研討會地點
研討會時間 20131004~20131008
通訊作者
國別 JPN
公開徵稿 Y
出版型式 電子版
出處 10th International Conference of the Asian Pacific Chitin Chitosan Symposium, pp. 249
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