Add-on Treatment of Benzoate for Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial of d-Amino Acid Oxidase Inhibitor
學年 102
學期 1
出版（發表）日期 2013-12-01
作品名稱 Add-on Treatment of Benzoate for Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial of d-Amino Acid Oxidase Inhibitor
作品名稱（其他語言）
著者 Lane, Hsien-Yuan; Lin, Ching-Hua; Michael F. Green; Gerhard Hellemann; Huang, Chih-Chia; Chen, Po-Wei; Tun, Rene; Chang, Yue-Cung; Tsai, Guochuan E.
單位 淡江大學數學學系
出版者 Chicago: American Medical Association
著錄名稱、卷期、頁數 JAMA Psychiatry 70(12), pp.1267-1275
摘要 Importance In addition to dopaminergic hyperactivity, hypofunction of the N-methyl-d-aspartate receptor (NMDAR) has an important role in the pathophysiology of schizophrenia. Enhancing NMDAR-mediated neurotransmission is considered a novel treatment approach. To date, several trials on adjuvant NMDA-enhancing agents have revealed beneficial, but limited, efficacy for positive and negative symptoms and cognition. Another method to enhance NMDA function is to raise the levels of d-amino acids by blocking their metabolism. Sodium benzoate is a d-amino acid oxidase inhibitor. Objective To examine the clinical and cognitive efficacy and safety of add-on treatment of sodium benzoate for schizophrenia. Design, Setting, and Participants A randomized, double-blind, placebo-controlled trial in 2 major medical centers in Taiwan composed of 52 patients with chronic schizophrenia who had been stabilized with antipsychotic medications for 3 months or longer. Interventions Six weeks of add-on treatment of 1 g/d of sodium benzoate or placebo. Main Outcomes and Measures The primary outcome measure was the Positive and Negative Syndrome Scale (PANSS) total score. Clinical efficacy and adverse effects were assessed biweekly. Cognitive functions were measured before and after the add-on treatment. Results Benzoate produced a 21% improvement in PANSS total score and large effect sizes (range, 1.16-1.69) in the PANSS total and subscales, Scales for the Assessment of Negative Symptoms–20 items, Global Assessment of Function, Quality of Life Scale and Clinical Global Impression and improvement in the neurocognition subtests as recommended by the National Institute of Mental Health’s Measurement and Treatment Research to Improve Cognition in Schizophrenia initiative, including the domains of processing speed and visual learning. Benzoate was well tolerated without significant adverse effects. Conclusions and Relevance Benzoate adjunctive therapy significantly improved a variety of symptom domains and neurocognition in patients with chronic schizophrenia. The preliminary results show promise for d-amino acid oxidase inhibition as a novel approach for new drug development for schizophrenia.
關鍵字
語言 en_US
ISSN 2168-622X 2168-6238
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 否
國別 USA
公開徵稿
出版型式 ,電子版,紙本
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