| Efficient Synthesis of Boron-Containing alpha-Acyloxyamide Analogs via Microwave Irradiation | |
|---|---|
| 學年 | 102 |
| 學期 | 1 |
| 出版（發表）日期 | 2013-08-08 |
| 作品名稱 | Efficient Synthesis of Boron-Containing alpha-Acyloxyamide Analogs via Microwave Irradiation |
| 作品名稱（其他語言） | |
| 著者 | Chai, Chih-Cheng; Liu, Pin-Yi; Lin, Chia-Hung; Chen, Hsien-Chi; Wu, Yang-Chang; Chang, Fang-Rong; Pan, Po-Shen |
| 單位 | 淡江大學化學學系 |
| 出版者 | Basel: M D P I AG |
| 著錄名稱、卷期、頁數 | Molecules 18(8), pp.9488-9511 |
| 摘要 | In this report, a Passerini three-component reaction utilizing boron-containing carboxylic acids or aldehydes is discussed. The reaction was carried out in water and facilitated by the use of microwave irradiation. This methodology allowed for the efficient formation of a broad range of boron-containing α-acyloxyamides under mild conditions within a short time. Two series of boron-containing α-acyloxyamides were synthesized and subsequently screened for cytotoxicity using the MTT cell viability assay. Two potential lead compounds were found to have potent activity against the HepG2 cancer cell line, demonstrating the potential of this methodology for use in the development of novel pharmaceuticals. |
| 關鍵字 | boron;multicomponent reaction;Passerini reaction;HepG2 |
| 語言 | en |
| ISSN | 1431-5165;1420-3049 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Pan, Po-Shen |
| 審稿制度 | 是 |
| 國別 | CHE |
| 公開徵稿 | |
| 出版型式 | ,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/92789 ) |
| SDGS | 良好健康和福祉 |
GoogleAnalytics