Synthesis of Boron-Containing Primary Amines
學年 102
學期 1
出版(發表)日期 2013-10-01
作品名稱 Synthesis of Boron-Containing Primary Amines
著者 Chung, Sheng-Hsuan; Lin, Ting-Ju; Hu, Qian-Yu; Tsai, Chia-Hua; Pan, Po-Shen
單位 淡江大學化學學系
出版者 Basel: M D P I AG
著錄名稱、卷期、頁數 Molecules 18(10), pp.12346-12367
摘要 In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate esters in good to excellent yields. These compounds were further utilized to build peptoid analogs via an Ugi four-component reaction (Ugi-4CR) under microwave irradiation. The prepared Ugi-4CR boronate esters were then successfully converted to the corresponding boronic acids. Finally, the peptoid structures were successfully modified by cross-coupling to aryl/heteroaryl chlorides via a palladium-mediated Suzuki coupling reaction to yield the corresponding derivatives in moderate to good yields.
語言 en
ISSN 1431-5165 1420-3049
期刊性質 國外
收錄於 SCI
通訊作者 Pan, Po-Shen
國別 CHE
出版型式 紙本

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