Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model
學年 101
學期 2
出版（發表）日期 2013-02-01
作品名稱 Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model
作品名稱（其他語言）
著者 Chen, Yau-hung; Wang, Wei-Hua; Wang, Yun-Hsin; Lin, Zi-Yu; Wen, Chi-Chung; Chern, Ching-Yuh
單位 淡江大學數學學系 淡江大學化學學系
出版者 Basel: M D P I AG
著錄名稱、卷期、頁數 Molecules 18(2), pp.2052-2060
摘要 The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
關鍵字 anti-inflammation; chalcone; fin; zebrafish
語言 en
ISSN 1431-5165 1420-3049
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Chen, Yau-hung; Chern, Ching-Yuh
審稿制度 是
國別 CHE
公開徵稿
出版型式 ,電子版,紙本
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