Mathematical model of heterogeneous cancer growth with an autocrine signalling pathway
學年 101
學期 1
出版（發表）日期 2012-10-01
作品名稱 Mathematical model of heterogeneous cancer growth with an autocrine signalling pathway
作品名稱（其他語言）
著者 Hu, G.-M.; Lee, C.-Y.; Chen, Y.-Y.; Pang, N.-N.; Tzeng, W. J.
單位 淡江大學物理學系
出版者 Chichester: Wiley-Blackwell Publishing Ltd.
著錄名稱、卷期、頁數 Cell Proliferation 45(5), pp.445-455
摘要 Objectives Cancer is a complex biological occurrence which is difficult to describe clearly and explain its growth development. As such, novel concepts, such as of heterogeneity and signalling pathways, grow exponentially and many mathematical models accommodating the latest knowledge have been proposed. Here, we present a simple mathematical model that exhibits many characteristics of experimental data, using prostate carcinoma cell spheroids under treatment. Materials and methods We have modelled cancer as a two-subpopulation system, with one subpopulation representing a cancer stem cell state, and the other a normal cancer cell state. As a first approximation, these follow a logistical growth model with self and competing capacities, but they can transform into each other by using an autocrine signalling pathway. Results and conclusion By analysing regulation behaviour of each of the system parameters, we show that the model exhibits many characteristics of actual cancer growth curves. Features reproduced in this model include delayed phase of evolving cancer under 17AAG treatment, and bi-stable behaviour under treatment by irradiation. In addition, our interpretation of the system parameters corresponds well with known facts involving 17AAG treatment. This model may thus provide insight into some of the mechanisms behind cancer.
關鍵字
語言 en_US
ISSN 1365-2184 0960-7722
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Hu, G.-M.
審稿制度 是
國別 USA
公開徵稿
出版型式 電子版 紙本
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