教師資料查詢 | 類別: 期刊論文 | 教師: 陳曜鴻CHEN, YAU-HUNG (瀏覽個人網頁)

標題:Cellular Uptake of a Polypyridyl Ruthenium Complex Revealed Using a Fluorescent Rhodamine-modified Ruthenium Complex
學年101
學期1
出版(發表)日期2012/09/01
作品名稱Cellular Uptake of a Polypyridyl Ruthenium Complex Revealed Using a Fluorescent Rhodamine-modified Ruthenium Complex
作品名稱(其他語言)
著者Jhou, Yu-Ru; Chiou, Chien-Hui; Ni, Lin-Kia; Chen, Li-Chou; Chen, Yau-Hung; Chen, Chien-Chung
單位淡江大學生命科學研究所
出版者Wiley-Blackwell Publishing Ltd.
著錄名稱、卷期、頁數Journal of the Chinese Chemical Society 59(9), pp.1053–1057
摘要A fluorescent polypyridyl ruthenium complex was successfully prepared using an amide bond linkage to link two rhodamine moieties through bipyridine groups. Although photo-induced electron transfer (PET) quenched the fluorescent intensity, the quantum yield of the rhodamine-modified Ru(II) complex was 0.17 in water, sufficient for observing the fluorophore behaviour in biological systems. The rhodaminemodified Ru(II) complex was found to inhibit the bacterial growth of E. coli. In vitro fluorescence images of human hepatoma cells (SK-Hep1) showed that a fluorescent polypyridyl ruthenium complex not only supported the above observation but also preferably accumulated in the cytoplasmic region inside the cell. These observations suggest that in addition to strong Ru–DNA interactions, Ru-protein interactions in the cytoplasmic regions are strong and are therefore important to the development of metallopharmaceuticals.
關鍵字Ruthenium;Rhodamine;Polypyridine;Uptake;Fluorescence
語言英文(美國)
ISSN2192-6549; 0009-4536
期刊性質國外
收錄於SCI
產學合作
通訊作者
審稿制度
國別英國
公開徵稿
出版型式電子版;紙本
相關連結
SDGs
Google+ 推薦功能,讓全世界都能看到您的推薦!