| Cellular Uptake of a Polypyridyl Ruthenium Complex Revealed Using a Fluorescent Rhodamine-modified Ruthenium Complex | |
|---|---|
| 學年 | 101 |
| 學期 | 1 |
| 出版（發表）日期 | 2012-09-01 |
| 作品名稱 | Cellular Uptake of a Polypyridyl Ruthenium Complex Revealed Using a Fluorescent Rhodamine-modified Ruthenium Complex |
| 作品名稱（其他語言） | |
| 著者 | Jhou, Yu-Ru; Chiou, Chien-Hui; Ni, Lin-Kia; Chen, Li-Chou; Chen, Yau-Hung; Chen, Chien-Chung |
| 單位 | 淡江大學生命科學研究所 |
| 出版者 | Wiley-Blackwell Publishing Ltd. |
| 著錄名稱、卷期、頁數 | Journal of the Chinese Chemical Society 59(9), pp.1053–1057 |
| 摘要 | A fluorescent polypyridyl ruthenium complex was successfully prepared using an amide bond linkage to link two rhodamine moieties through bipyridine groups. Although photo-induced electron transfer (PET) quenched the fluorescent intensity, the quantum yield of the rhodamine-modified Ru(II) complex was 0.17 in water, sufficient for observing the fluorophore behaviour in biological systems. The rhodaminemodified Ru(II) complex was found to inhibit the bacterial growth of E. coli. In vitro fluorescence images of human hepatoma cells (SK-Hep1) showed that a fluorescent polypyridyl ruthenium complex not only supported the above observation but also preferably accumulated in the cytoplasmic region inside the cell. These observations suggest that in addition to strong Ru–DNA interactions, Ru-protein interactions in the cytoplasmic regions are strong and are therefore important to the development of metallopharmaceuticals. |
| 關鍵字 | Ruthenium;Rhodamine;Polypyridine;Uptake;Fluorescence |
| 語言 | en_US |
| ISSN | 2192-6549; 0009-4536 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 是 |
| 國別 | GBR |
| 公開徵稿 | |
| 出版型式 | 電子版 紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/79664 ) |
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