| UV-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of broccoli and cauliflower extracts | |
|---|---|
| 學年 | 99 |
| 學期 | 1 |
| 出版（發表）日期 | 2011-01-01 |
| 作品名稱 | UV-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of broccoli and cauliflower extracts |
| 作品名稱（其他語言） | |
| 著者 | Chen, Yau-hung; Wen, Chi-chung; Lin, Chun-yun; Chou, Chi-yuan; Yang, Zhi-shiang; Wang, Yun-hsin |
| 單位 | 淡江大學生命科學研究所; 淡江大學數學學系 |
| 出版者 | New York: Informa Healthcare |
| 著錄名稱、卷期、頁數 | Toxicology Mechanisms and Methods 21(1), pp.63-69 |
| 摘要 | This study applied broccoli and cauliflower extracts (whole, floret, and stem) to zebrafish larvae in parallel to receive 100 mJ/cm2 of UVB six times, and recorded their fin malformation phenotypes. Chemopreventive effects of each group, including UVB, whole-, floret-, and stem-extracts of broccoli and cauliflower on fin development were evaluated using Kaplan-Meier analysis, log-rank test, and Cox proportional hazards regression. Results showed that (1) zebrafish fins in the UVB + whole broccoli extract group are 6.20~9.32-times more likely to return to normal fins than ones in the UVB only group, but fins in the UVB + whole cauliflower extract group are only 5.13~11.10-times more likely to recover, indicated that whole broccoli and cauliflower extract had similar chemopreventive ability on fin development; and (2) the broccoli stem has the highest antioxidant capacity among other groups. In conclusion, zebrafish can be used as a system for evaluating the efficacy of other UVB protective compounds. |
| 關鍵字 | Broccoli; cauliflower; fin; skin cancer; UVB; zebra fish |
| 語言 | en_US |
| ISSN | 1537-6516 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Wang, Yun-hsin |
| 審稿制度 | |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | 紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/77039 ) |
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