Immobilization of heparin on PVDF membranes with microporous structures
學年 93
學期 1
出版（發表）日期 2004-12-01
作品名稱 Immobilization of heparin on PVDF membranes with microporous structures
作品名稱（其他語言）
著者 Lin, Dar-jong; Lin, Dong-tsamn; Young, Tai-horng; Huang, Fang-ming; Chen, Ching-chung; Cheng, Liao-ping
單位 淡江大學化學工程與材料工程學系
出版者
著錄名稱、卷期、頁數 Journal of membrane science 245(1-2), pp.137-146
摘要 Heparin (an anti-thrombin) was immobilized onto microporous poly (vinylidene fluoride) (PVDF) membranes that were prepared either by dry or immersion precipitation method. Immobilization of heparin was carried out by a procedure consisted of two steps. First, poly (acrylic acid) (PAA) was grafted on PVDF membranes with various surface porosities by plasma-induced polymerization. Then, heparin was covalently bonded to PAA with the aid of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDAC). The highest attainable grafting yield of PAA was 0.68 mg/cm2. For heparin immobilization, it was found that the preparation parameters such as, EDAC activation time, concentration of reactants, and pH affected significantly the amount of immobilized heparin. The maximal value was 9.68 μg/cm2. Furthermore, blood compatibility tests were carried out on membranes with and without heparin by platelet adhesion method. The results indicated that immobilized-heparin could effectively inhibit platelet adhesion on the membranes.
關鍵字 Composite membranes; Plasma polymerized membranes; Immobilization; Heparin
語言 en
ISSN
期刊性質 國外
收錄於 SCI EI
產學合作
通訊作者
審稿制度 否
國別 TWN
公開徵稿
出版型式 ,電子版
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