教師資料查詢 | 類別: 期刊論文 | 教師: 陳錦華 CHEN CHIN-HUA (瀏覽個人網頁)

標題:Bayesian Analysis of the Population Case-Control Studies When the Population is in Hardy-Weinberg Equilibrium
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學期
出版(發表)日期2005/02/01
作品名稱Bayesian Analysis of the Population Case-Control Studies When the Population is in Hardy-Weinberg Equilibrium
作品名稱(其他語言)
著者陳錦華; Chen, Jin-hua
單位淡江大學統計學系
出版者
著錄名稱、卷期、頁數Genetics Epidemiology 28(2), pp.183-193
摘要Association analysis of genetic polymorphisms has been mostly performed in a case-control setting with unrelated affected subjects compared with unrelated unaffected subjects. In this paper, we present a Bayesian method for analyzing such case-control data when the population is in Hardy-Weinberg equilibrium. Our Bayesian method depends on the informative prior which is the retrospective likelihood based on historical data, raised to a power a. By modeling the retrospective likelihood properly, different prior information about the studied population can be incorporated into the specification of the prior. The scalar a is a precision parameter quantifying the heterogeneity between current and historical data. A guide value for a is discussed in this paper. The informative prior and posterior distributions are proper under very general conditions. Therefore, our method can be applied in most case-control studies. Further, for assessing gene-environment interactions, our approach will naturally lead to a Bayesian model depending only on the case data, when genotype and environmental factors are independent in the population. Thus our approach can be applied to case-only studies. A real example is used to show the applications of our method.
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語言英文(美國)
ISSN0741-0395
期刊性質國外
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產學合作
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國別美國
公開徵稿
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