An Adaptive Design for Categorical Responses in Phase III Clinical Trials
學年 95
學期 1
出版（發表）日期 2007-01-01
作品名稱 An Adaptive Design for Categorical Responses in Phase III Clinical Trials
作品名稱（其他語言）
著者 黃文濤; Atanu Biswas; Rahul Bhattacharya
單位 淡江大學經營決策學系
出版者
著錄名稱、卷期、頁數 International Journal of Information and Management Sciences 18(1), pp.1-16
摘要 An adaptive design is provided for phase III clinical trials where the treatment responses are categorical. The proposed design extends the drop-the-loser rule (Ivanova [10]) which is proposed for binary treatment responses only. It is illustrated that the proposed design is an improvement over the existing design of Bandyopadhyay and Biswas [3] for such categorical responses in terms of low variability. Some probability generating functions of the proposed design are obtained. The applicability of the proposed design is illustrated by using some real data from an trial of patients of rheumatoid arthritis.
關鍵字 immigration ball;limiting proportion of allocation;ordinal categorical responses;proportion of allocation;randomisation;response-driven adaptive design;treatment difference;urn model
語言 en_US
ISSN 1017-1819
期刊性質 國內
收錄於
產學合作
通訊作者
審稿制度 否
國別 TWN
公開徵稿
出版型式 ,紙本
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