CoII(HAPP)(TFA)2 complexes : a DNA bulge-specific probe
學年 87
學期 2
出版(發表)日期 1999-05-12
作品名稱 CoII(HAPP)(TFA)2 complexes : a DNA bulge-specific probe
作品名稱(其他語言)
著者 Wang, Wen-jwu
單位 淡江大學化學學系
出版者
著錄名稱、卷期、頁數 Angewandte Chemie: International Edition in English 38(9),  p.1255-1257
摘要 Bulge cleavage of two or three bases occurs when a DNA substrate is specifically cleaved oxidatively by [CoII(tfa)2(happ)] (see picture). Hydrogen peroxide is necessary for the activation of this octahedral complex, which suggests that hydroxyl radicals are the reactive species. The complex has no significant reactivity towards the corresponding sequence in a single-stranded DNA region, and it exhibits only a low affinity towards double-stranded DNA. happ=macrocyclic ligand based on 1,10-phenanthroline, tfa=trifluoroacetate.
關鍵字 Cobalt;DNA cleavage;DNA structures;Macrocycles;N ligands
語言 en
ISSN 1433-7851
期刊性質 國外
收錄於
產學合作
通訊作者
審稿制度
國別 DEU
公開徵稿
出版型式 ,紙本
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