| CoII(HAPP)(TFA)2 complexes : a DNA bulge-specific probe | |
|---|---|
| 學年 | 87 |
| 學期 | 2 |
| 出版（發表）日期 | 1999-05-12 |
| 作品名稱 | CoII(HAPP)(TFA)2 complexes : a DNA bulge-specific probe |
| 作品名稱（其他語言） | |
| 著者 | Wang, Wen-jwu |
| 單位 | 淡江大學化學學系 |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Angewandte Chemie: International Edition in English 38(9), p.1255-1257 |
| 摘要 | Bulge cleavage of two or three bases occurs when a DNA substrate is specifically cleaved oxidatively by [CoII(tfa)2(happ)] (see picture). Hydrogen peroxide is necessary for the activation of this octahedral complex, which suggests that hydroxyl radicals are the reactive species. The complex has no significant reactivity towards the corresponding sequence in a single-stranded DNA region, and it exhibits only a low affinity towards double-stranded DNA. happ=macrocyclic ligand based on 1,10-phenanthroline, tfa=trifluoroacetate. |
| 關鍵字 | Cobalt;DNA cleavage;DNA structures;Macrocycles;N ligands |
| 語言 | en |
| ISSN | 1433-7851 |
| 期刊性質 | 國外 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | DEU |
| 公開徵稿 | |
| 出版型式 | ,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/61529 ) |
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