Effects of collisional cooling on ion detection in a quadrupole ion trap mass spectrometer
學年 80
學期 2
出版（發表）日期 1992-05-05
作品名稱 Effects of collisional cooling on ion detection in a quadrupole ion trap mass spectrometer
作品名稱（其他語言）
著者 Wu, H. F. ; 吳慧芬; Brodbelt, J. S.
單位 淡江大學化學學系
出版者
著錄名稱、卷期、頁數 International Journal of Mass Spectrometry and Ion Processes 115(1), pp.67-81
摘要 The effects of collisional cooling on the storage and detection of ions in a quadrupole ion trap mass spectrometer are examined. Four parameters that affect the storage of ions are evaluated: the pressure of the buffer gas: the qz value which establishes the ion trapping environment; the cooling time during which ions may collapse to the center of the trap; and the supplementary a.c. voltage used to kinetically excite selected ions. The ion trap may be operated effectively at a low helium pressure (0.1 mTorr) if a sufficient delay period is added to allow the diffuse ion cloud to collapse to the center of the trap prior to detection. For a typical experiment, this modified operation at low pressures involves allowing the ions to undergo approximately 30–100 collisions (i.e. in a ≈30 ms interval at 0.1 mTorr). At low helium pressures (≈0.1 mTorr), more ions may be trapped at higher qz values. Collision-activated dissociation (CAD) at low helium pressures indicates that the average internal energy deposition is higher, and sensitivity is not lost, if a collisional cooling delay is added. This latter result potentially has great analytical relevance for CAD of biomolecules which require greater internal energy deposition to induce fragmentation.
關鍵字 collisional cooling;collision-activated dissociation;ion detection
語言 en
ISSN 0168-1176 0020-7381
期刊性質 國外
收錄於
產學合作
通訊作者
審稿制度 否
國別 NLD
公開徵稿
出版型式 ,電子版,紙本
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