教師資料查詢 | 類別: 期刊論文 | 教師: 簡丞志 CHENG-CHIH CHIEN (瀏覽個人網頁)

標題:A novel statistical cut-strategy for DP-based multiple biosequence alignment
學年
學期
出版(發表)日期2005/11/01
作品名稱A novel statistical cut-strategy for DP-based multiple biosequence alignment
作品名稱(其他語言)
著者簡丞志
單位淡江大學電機工程學系
出版者
著錄名稱、卷期、頁數TENCON 2005 IEEE Region 10, pp.419-424
摘要In this paper, a novel cut-strategy is presented for solving the problems of multiple biosequence alignment. Sequence comparison is the most important primitive operation for analyzing of the bioinformatics data. The most fundamental method for alignment of several biosequences is the dynamic programming (DP) technique. The DP method is capable of finding optimal alignments for a set of sequences. However, when the length of the sequences increased, the DP method is impracticable due to the computational complexity is extremely high. Therefore, a new method is proposed in this paper for reducing the computational cost of the DP technique. By recursively finding the structural features of the biosequences, the proposed method can divide the biosequences into very small alignment problem, which can be directly solved by DP, or other applicable methods that can produce the results of alignment faster. By utilizing the object-oriented programming technique, the proposed method also provides low memory space consumption during execution. Moreover, the proposed algorithm has been implemented in an x86 demonstration program, and compares the effective and efficient performance with other known method.
關鍵字Sequences;Bioinformatics;Computational complexity;Dynamic programming;RNA;Computational efficiency;Object oriented programming;Computational biology;Biology computing;High performance computing
語言英文(美國)
ISSN0886-1420
期刊性質國外
收錄於
產學合作
通訊作者
審稿制度
國別美國
公開徵稿
出版型式,紙本
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