Synthesis of chitosan-poly(Acrylic Acid) complex particles by dispersion polymerization and their applications in ph buffering and drug release
學年 99
學期 2
出版（發表）日期 2011-05-01
作品名稱 Synthesis of chitosan-poly(Acrylic Acid) complex particles by dispersion polymerization and their applications in ph buffering and drug release
作品名稱（其他語言）
著者 Chuang, Chung-Yang; Chiu, Wen-Yen; Don, Trong-Ming
單位 淡江大學化學工程與材料工程學系
出版者 Hoboken: John Wiley & Sons, Inc.
著錄名稱、卷期、頁數 Journal of Applied Polymer Science 120(3), pp.1659–1670
摘要 This research prepared polyelectrolyte complex particles of chitosan-poly(acrylic acid) (CS-PAA) through polymerization of acrylic acid (AA) in the presence of chitosan (CS). The prepared CS-PAA complex particles had positive zeta potential and dispersed very well in the aqueous solution. Structure and morphology of complex particles were investigated with the changes in the feeding molar ratio of glucosamine unit in CS to AA monomer. It was found at a molar ratio of 1.0/1.1, a hollow structure in complex particles was observed after polymerization. From solid state 13C-NMR and FTIR analyses, the results confirmed that CS-co-PAA copolymer was also produced during polymerization in addition to the PAA homopolymer, and both constituted in the structure of complex particles. The synthesized complex particles were environmentally sensitive in which their mean diameter could change with the pH value of medium. Moreover, the complex particles showed a continuous release of the encapsulated doxycycline hyclate up to 8 days. These complex particles with environmentally sensitive properties are expected to be utilized in the hydrophilic drug delivery system.
關鍵字 chitosan;poly(acrylic acid);complex particles;hollow structure;drug delivery
語言 en
ISSN 1097-4628
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Don, Trong-Ming
審稿制度
國別 USA
公開徵稿
出版型式 電子版
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