| A statistical assessment on the stochastic relationship between biomarker concentrations and environmental exposures | |
|---|---|
| 學年 | 93 |
| 學期 | 1 |
| 出版（發表）日期 | 2004-12-01 |
| 作品名稱 | A statistical assessment on the stochastic relationship between biomarker concentrations and environmental exposures |
| 作品名稱（其他語言） | |
| 著者 | 陳主智; Chen, Chu-chih; Wu, Kuen-yuh; Chang, Ming J. W. |
| 單位 | 淡江大學數學學系 |
| 出版者 | Springer |
| 著錄名稱、卷期、頁數 | Stochastic Environmental Research and Risk Assessment 18(6), pp.377-385 |
| 摘要 | Biological monitoring has gradually developed into a powerful tool in the identification and quantification of exposures to occupational and/or environmental hazards in environmental and occupational health studies. Aggregate individual exposure to pollutants and evidence for exploring dose-response relationship in the human bodies can be assessed through biomarker measurements. The existence of inter-individual differences among a study population, however, often hampers the relationship assessment between exposure and the biomarker. In this paper, a statistical random effects model identified from a simplified one-compartment pharmacokinetic model is applied to establish the dynamic relationship between a biomarker and its corresponding external exposure. This model avoids the complex parameter estimation problem encountered using a physiologically based pharmacokinetic (PBPK) model, and incorporates inter-individual variations often ignored in the usual regression approach. In addition, the relevant parameters for the generic kinetic process can be estimated directly. As a guideline for preliminary sampling strategy, tables of required sample sizes and the number of repeated measurements to achieve the desired statistical power and test efficiency are given. The currently established biological exposure indices (BEIs) for benzene and methyl chloroform are employed to illustrate the impact of inter- individual variations on the percentages of protection for workers exposed to the threshold limit value (TLV) of the corresponding chemical. |
| 關鍵字 | Biological exposure indices;Inter-individual difference;Random-effects model;Physiologically-based pharmacokinetic model;Sampling design Threshold limit value |
| 語言 | en |
| ISSN | 1436-3240 |
| 期刊性質 | 國外 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | TWN |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/41464 ) |
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