教師資料查詢 | 類別: 期刊論文 | 教師: 溫啟仲 WEN,CHI-CHUNG (瀏覽個人網頁)

標題:Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus
學年
學期
出版(發表)日期2006/09/01
作品名稱Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus
作品名稱(其他語言)
著者Jiang, Shih-sheng; Chang, I-shou; Huang, Lin-wei; Chen, Po-cheng; Wen, Chi-chung; Liu, Shu-chen; Chien, Li-chu; Lin, Chung-yen; Hsiung, Chao A.; Juang, Jyh-lyh
單位淡江大學數學學系
出版者American Society for Microbiology
著錄名稱、卷期、頁數Journal of Virology 80(18), pp.8989-8999
摘要Baculoviruses, a family of large, rod-shaped viruses that mainly infect lepidopteran insects, have been widely used to transduce various cells for exogenous gene expression. Nonetheless, how a virus controls its transcription program in cells is poorly understood. With a custom-made baculovirus DNA microarray, we investigated the recombinant Autographa californica multiple nucleopolyhedrosis virus (AcMNPV) gene expression program in lepidopteran Sf21 cells over the time course of infection. Our analysis of transcription kinetics in the cells uncovered sequential viral gene expression patterns possibly regulated by different mechanisms during different phases of infection. To gain further insight into the regulatory network, we investigated the transcription program of a mutant virus deficient in an early transactivator (pe38) and uncovered several pe38-dependent and pe38-independent genes. This study of baculovirus dynamic transcription programs in different virus genetic backgrounds provides new molecular insights into how gene expression in viruses is regulated.
關鍵字
語言英文
ISSN0022-538X
期刊性質國外
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產學合作
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審稿制度
國別美國
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