Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus
學年 95
學期 1
出版（發表）日期 2006-09-01
作品名稱 Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus
作品名稱（其他語言）
著者 Jiang, Shih-sheng; Chang, I-shou; Huang, Lin-wei; Chen, Po-cheng; Wen, Chi-chung; Liu, Shu-chen; Chien, Li-chu; Lin, Chung-yen; Hsiung, Chao A.; Juang, Jyh-lyh
單位 淡江大學數學學系
出版者 American Society for Microbiology
著錄名稱、卷期、頁數 Journal of Virology 80(18), pp.8989-8999
摘要 Baculoviruses, a family of large, rod-shaped viruses that mainly infect lepidopteran insects, have been widely used to transduce various cells for exogenous gene expression. Nonetheless, how a virus controls its transcription program in cells is poorly understood. With a custom-made baculovirus DNA microarray, we investigated the recombinant Autographa californica multiple nucleopolyhedrosis virus (AcMNPV) gene expression program in lepidopteran Sf21 cells over the time course of infection. Our analysis of transcription kinetics in the cells uncovered sequential viral gene expression patterns possibly regulated by different mechanisms during different phases of infection. To gain further insight into the regulatory network, we investigated the transcription program of a mutant virus deficient in an early transactivator (pe38) and uncovered several pe38-dependent and pe38-independent genes. This study of baculovirus dynamic transcription programs in different virus genetic backgrounds provides new molecular insights into how gene expression in viruses is regulated.
關鍵字
語言 en
ISSN 0022-538X
期刊性質 國外
收錄於
產學合作
通訊作者
審稿制度 否
國別 USA
公開徵稿
出版型式 ,電子版
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