ShyA, a membrane protein for proper septation of hyphae in Streptomyces
學年 94
學期 2
出版（發表）日期 2006-05-05
作品名稱 ShyA, a membrane protein for proper septation of hyphae in Streptomyces
作品名稱（其他語言）
著者 Tseng, Shun-fu; Huang, Tzu-wen; Chen, Carton W.; Chern, Ming-kai; Tam, Ming F.; Teng, Shu-chun
單位 淡江大學生命科學研究所
出版者 Maryland Heights: Elsevier Inc
著錄名稱、卷期、頁數 Biochemical and Biophysical Research Communications 343(2), pp.369-377
摘要 The life cycle of Streptomyces involves the formation of filamentous substrate and aerial hyphae. Following cessation of growth of an aerial hypha, multiple septation occurs at the tip to produce a chain of unigenomic spores. A gene, shyA, which influences several aspects of this growth, was isolated and partially characterized in Streptomyces coelicolor. The gene product is a representative of a well-conserved family of small actinomycete proteins. The shyA mutant sporulates normally but displays hyper septum formation and altered spore-chain morphology. Biochemical separation experiments and immunofluorescence staining demonstrated that the shyA gene product locates at cell membranes. Moreover, yeast two-hybrid screen and GST-pull-down assay showed that ShyA can interact with itself. Altogether, ShyA belongs to a new family of membrane-associated proteins which plays a role in morphological differentiation in actinomycetes.
關鍵字 Streptomyces; Actinomycetes; Hyphae; Spore; Membrane protein
語言 en
ISSN 0006-291X
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Teng, Shu-chun
審稿制度
國別 USA
公開徵稿
出版型式 紙本
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