From an Integrated Biochip Detection System to a Defensive Weapon Against the SARS-CoV Virus: OBMorph
學年 92
學期 2
出版（發表）日期 2004-06-01
作品名稱 From an Integrated Biochip Detection System to a Defensive Weapon Against the SARS-CoV Virus: OBMorph
作品名稱（其他語言）
著者 Lee, Chih-kung; Lin, Chi-wan; Lin, Shi-ming; 李世元; Lee, Adam Shih-yuan; Wu, Jiun-yan; Lee, Shu-sheng; Hsiao, Wen-hsin; Chen, Shih-jui; Wang, An-bang
單位 淡江大學化學學系
出版者 Materials Research Society
著錄名稱、卷期、頁數 Materials Research Society symposium proceedings 820
摘要 In this paper, an integrated multifunctional biochip detection system, which we call “OBMorph“, are presented. This unique system integrates several optoelectronic-based biological diagnostic tools such as an ellipsometer, a laser Doppler vibrometer/interferometer, a SPR (surface plasmon resonance) analyzer, an interference microscope, a photon tunneling microscope, an optical coherence tomography unit and a confocal scanning microscope. This OBMorph system, useful as a powerful optical metrology diagnostic tool, can be used at the beginning of sensor chip fabrication, on to signal detecting and monitoring, and to the final biological analysis. The principles and experimental results of this multifunctional biochip detection OBMorph system are presented. In addition, an innovative SARS (Severe Acute Respiratory Syndrome) virus denaturing chemical compound that was derived using the OBMorph system to study biolinker fabrication in biochips, are discussed. Several testing strategies are presented herein which proves the effectiveness of the new chemical compound, biochip technology in denaturing the SARS virus. Analysis under an atomic force microscope confirms the actual breaking down of the virus treated by the chemical compound. The fundamentals of how the chemical compound denatures the virus and renders it toxicity useless, is based on principles of nanotechnology and bio-mechanics. Results from preliminary studies show that this denaturing principle can be also effective against other deadly viruses and even bacteria. Some design strategies and innovative working mechanisms derived from study of this chemical compound which can denature the SARS-CoV, are also discussed.
關鍵字
語言 en_US
ISSN 0272-9172
期刊性質 國外
收錄於
產學合作
通訊作者
審稿制度 否
國別 USA
公開徵稿
出版型式 ,紙本
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