期刊論文
| 學年 | 109 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2020-11-13 |
| 作品名稱 | Copper-Catalyzed Dual Cyclization for the Synthesis of Quinindolines |
| 作品名稱（其他語言） | |
| 著者 | Hung-Kai Wang; Yu-Lun Chio; Gangaram Pallikonda; Hsyueh-Liang Wu; Haw-Lih Su; Jen-Chieh Hsieh(謝仁傑) |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Molecules 25(22), 5303 |
| 摘要 | A synthetic approach to quinindoline derivatives by the Cu-catalyzed dual cyclization has been developed. This catalytic reaction is a practical method for the systematic synthesis of quinindoline core structure, which contains a limited-step synthetic strategy and can tolerant a wide variety of substituents. In addition, the mechanistic study reveals that the reaction initiates from a Lewis acid accelerated addition of aniline to nitrile and provides the indole substructure, and then the subsequent Cu-catalyzed C-N coupling reaction furnishes the quinoline subunit and affords the quinindoline structure. |
| 關鍵字 | copper-catalyzed;quinindoline;natural alkaloid;N-heterocycle;cyclization |
| 語言 | en |
| ISSN | 1420-3049 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | CHE |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/120973 ) |