期刊論文
| 學年 | 102 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2014-06-01 |
| 作品名稱 | Introduction of Cysteine Dioxygenase: Structural Biology, Proposed Reaction Mechanisms and Biomimetic Model Complexes |
| 作品名稱（其他語言） | 半胱胺酸雙加氧酶 (Cysteine Dioxygenase)之功能與介紹及其模型化合物的研究與發展 |
| 著者 | Sen-Jer Lee, Jing-Yi Huang, Chung-Hung Hsieh |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | 72卷2期 |
| 摘要 | There is a variety of metalloenzymes in the biological system. The organisms use them to maintain their life. Herein, we introduce a special enzyme: Cysteine Dioxygenase (CDO); CDO is a non-heme iron enzyme, which can convert cysteine (Cys) into cysteine sulfinic acid (CSA). This conversion plays an important role in cysteine catabolism in mammalian tissue. Deficiency of CDO has been correlated with Alzheimer’s, Parkinson’s and other neurological disorders. Structural comparison from the typical non-hemeFe(II) dioxygenases to CDO, the coordination sphere of the Fe in CDO deviates fromthe fac-2-Histeines-1-carboxylate to a 3-Histeines facial triad. Themechanistic information of CDO, involves in O2 activation to generate Fe(III)-O2 − or further leading to the formation of Fe(IV) = O species, is still not clear. Biomimetic studies suggest the S-oxygenation mediatedby an Fe(II)-SR complex and O2 is expectable. |
| 關鍵字 | Cysteine Dioxygenase;CDO |
| 語言 | zh_TW |
| ISSN | |
| 期刊性質 | 國內 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | Chung-Hung Hsieh |
| 審稿制度 | 是 |
| 國別 | TWN |
| 公開徵稿 | |
| 出版型式 | ,電子版,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/111952 ) |