會議論文
| 學年 | 102 |
|---|---|
| 學期 | 2 |
| 發表日期 | 2014-07-02 |
| 作品名稱 | Epitope and Paratope Region Analysis |
| 作品名稱（其他語言） | |
| 著者 | Ying-Tsang Lo; Tun-Wen Pai; Hui-Huang Hsu; Huai-Kuang Tsai |
| 作品所屬單位 | |
| 出版者 | |
| 會議名稱 | Eighth International Conference on Complex, Intelligent and Software Intensive Systems (CISIS 2014) |
| 會議地點 | Birmingham, UK |
| 摘要 | Print Request Permissions A conformational epitope (CE) in an antigenic protein is composed of amino acid residues that are spatially near each other on the antigen's surface but discontinuously appeared in sequence. CEs bind their complementary Para topes which are located on the surface areas of B-cell receptors and/or antibodies. CE predication is a challenging research topic, which plays an important and fundamental role for vaccine design and immuno-biological experiments. The aim of this study is to primarily analyze CE epitopes of 163 non-redundant antigen structures based on physical and chemical properties of surface residues. In terms of physical properties, distinguishable geometric features of solid angle and surface rate of amino acids are observed, while for chemical properties, higher energy, hydrophilicity and polarity from verified epitope regions are discovered as well. All these recognized features from verified CEs were thoroughly analyzed and compared for supporting a CE prediction system. |
| 關鍵字 | bioinformatics;computational geometry;proteins |
| 語言 | en |
| 收錄於 | |
| 會議性質 | 國際 |
| 校內研討會地點 | 無 |
| 研討會時間 | 20140702~20140704 |
| 通訊作者 | |
| 國別 | GBR |
| 公開徵稿 | |
| 出版型式 | |
| 出處 | Eighth International Conference on Complex, Intelligent and Software Intensive Systems (CISIS 2014), pp.510-514 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/106408 ) |