期刊論文
| 學年 | 103 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2015-06-22 |
| 作品名稱 | Cobalt-Catalyzed Dual Annulation of o-Halobenzaldimine with Alkyne: A Powerful Route toward Bioactive Indenoisoquinolinones |
| 作品名稱（其他語言） | |
| 著者 | 謝仁傑 |
| 單位 | |
| 出版者 | Wiley |
| 著錄名稱、卷期、頁數 | Chemistry 21(26), p.9544–9549 |
| 摘要 | A cobalt-catalyzed dual annulation reaction for the synthesis of variously substituted indenoisoquinolinones from 2-bromobenzaldehydes, amines, and methyl 2-(ethynyl)benzoates has been developed. This method could also be applied to the synthesis of an array of highly functionalized bioactive indenoisoquinolinones and their derivatives. A possible mechanism of the cobalt catalysis is proposed, involving imine formation from bromobenzaldehyde and the amine, followed by a series of oxidative addition, alkyne insertion, cyclization reactions, and carbon-carbon double-bond migration. The regioselective alkyne insertion plays an important role for the success of the second annulation. |
| 關鍵字 | azametallacycles;cobalt;indenes;isoquinoline;zinc |
| 語言 | en |
| ISSN | 0972-8376 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | 謝仁傑 |
| 審稿制度 | 是 |
| 國別 | DEU |
| 公開徵稿 | |
| 出版型式 | ,電子版,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/103480 ) |