期刊論文
| 學年 | 102 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2014-03-31 |
| 作品名稱 | Identification of Simple Sequence Repeat Biomarkers through Cross-Species Comparison in a Tag Cloud Representation |
| 作品名稱（其他語言） | |
| 著者 | Huang, Jhen-Li; Chang, Hao-Teng; Cheng, Ronshan; Hsu, Hui-Huang; Pai, Tun-Wen |
| 單位 | 淡江大學資訊工程學系 |
| 出版者 | America: Hindawi Publishing Corporation |
| 著錄名稱、卷期、頁數 | BioMed Research International 2014(2014), 678971(11pages) |
| 摘要 | Simple sequence repeats (SSRs) are not only applied as genetic markers in evolutionary studies but they also play an important role in gene regulatory activities. Efficient identification of conserved and exclusive SSRs through cross-species comparison is helpful for understanding the evolutionary mechanisms and associations between specific gene groups and SSR motifs. In this paper, we developed an online cross-species comparative system and integrated it with a tag cloud visualization technique for identifying potential SSR biomarkers within fourteen frequently used model species. Ultraconserved or exclusive SSRs among cross-species orthologous genes could be effectively retrieved and displayed through a friendly interface design. Four different types of testing cases were applied to demonstrate and verify the retrieved SSR biomarker candidates. Through statistical analysis and enhanced tag cloud representation on defined functional related genes and cross-species clusters, the proposed system can correctly represent the patterns, loci, colors, and sizes of identified SSRs in accordance with gene functions, pattern qualities, and conserved characteristics among species. |
| 關鍵字 | |
| 語言 | en |
| ISSN | 2314-6141 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 是 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | 電子版 紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/100102 ) |