期刊論文
| 學年 | 101 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2013-03-01 |
| 作品名稱 | Amikacin-induced Fin Reduction is Mediated by Autophagy |
| 作品名稱（其他語言） | |
| 著者 | Tsai, I-Ting; Chen, Yau-Hung; Wang, Yun-Hsin |
| 單位 | 淡江大學生命科學研究所 |
| 出版者 | Tokyo: Japanese Society of Toxicologic Pathology |
| 著錄名稱、卷期、頁數 | Journal of Toxicologic Pathology 26(1), pp.79-82 |
| 摘要 | Despite its medical use, little is known about the mechanisms underlying amikacin-induced embryotoxicity, including fin reduction, in zebrafish. In this study, we examined the expression of well-known autophagy markers mTOR (target of rapamycin), atg10 (autophagy-related gene), atg12 and LC3 (mammalian homolog of Atg8) in amikacin-treated zebrafish embryos. Our results indicated that the mRNA expression level of atg12 in the amikacin-treated group was significantly increased by 1.5-fold (p＜0.05) compared with the corresponding mock control group, while the expression levels of atg10 and mTOR were significantly decreased by 0.74-fold (p＜0.05) and 0.58-fold (p＜0.05), respectively. Western blot analysis revealed that LC3 protein expression was induced by amikacin. Taken together, these data suggest that amikacin-induced fin reduction is mediated by fin cell autophagy. |
| 關鍵字 | amikacin; autophagy; embryotoxicity; fin reduction; zebrafish |
| 語言 | en_US |
| ISSN | 0914-9198 1347-7404 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Chen, Yau-Hung; Wang, Yun-Hsin |
| 審稿制度 | 是 |
| 國別 | JPN |
| 公開徵稿 | |
| 出版型式 | ,電子版,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/91702 ) |