期刊論文
| 學年 | 100 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2012-07-01 |
| 作品名稱 | An Alternative Synthesis of 3′,4′-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae |
| 作品名稱（其他語言） | |
| 著者 | Shih, Tzenge-Lien; Hsiao, Chih-Ang; Lin, Zi-Yu; Chen, Yau-Hung |
| 單位 | 淡江大學化學學系 |
| 出版者 | Basel: M D P I AG |
| 著錄名稱、卷期、頁數 | Molecules 17(7), pp.8206-8216 |
| 摘要 | We described herein a concise synthesis of 3′,4′-diaminoflavone 10. This new, three-step synthetic approach is more efficient than the conventional seven-step synthetic method. The route is shortened significantly by introducing the amino moieties early and eliminating the need for nitro group reduction. The other two analogues, 5,7-dihydroxy-3′,4′-diaminoflavone 11 and 5,7-dimethoxy-3′,4′-diaminoflavone 12, were also synthesized similarly. The above three compounds, along with flavone, were evaluated for their antioxidant and UVB-protection abilities on zebrafish larvae. The data showed that compound 10 exhibited the best result, with −102.3% of ROS-scavenging rate. |
| 關鍵字 | antioxidant; Baker-Venkataraman; rearrangement; diaminoflavones; ROS-scavenging; zebrafish larvae |
| 語言 | en_US |
| ISSN | 1431-5165 1420-3049 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Shih, Tzenge-Lien; Chen, Yau-Hung |
| 審稿制度 | 是 |
| 國別 | CHE |
| 公開徵稿 | |
| 出版型式 | 電子版 紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/79665 ) |