期刊論文
| 學年 | 100 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2012-02-01 |
| 作品名稱 | Fin reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos |
| 作品名稱（其他語言） | |
| 著者 | Chen, Ying-Hsin; Tsai, I-Ting; Wen, Chi-Chung; Wang, Yun-Hsin; Cheng, Chien-Chung; Hu, Sheng-Chuan; Chen, Yau-Hung |
| 單位 | 淡江大學數學學系; 淡江大學化學學系 |
| 出版者 | New York: Informa Healthcare |
| 著錄名稱、卷期、頁數 | Toxicology Mechanisms and Methods 22(2), p.151-158 |
| 摘要 | We used zebrafish as a model to assess amikacin-induced embryotoxicity. We exposed zebrafish embryos to amikacin, using different amikacin doses (0-10 ppm), durations (12-48 h), and onsets (0, 24, 48 hpf). Amikacin-induced embryonic toxicity and reduced survival rate were found dependent on the exposure dose, duration and onset. Based on immunostaining with neuron-specific antibodies, amikacin reduced the number and size of zebrafish neuromasts. In addition, Amikacin caused pelvic, dorsal and anal fin defects in dose-dependent and duration-dependent manners. Proliferating cell nuclear antigen immunostaining revealed that amikacin-induced fin defects were not due to reduction of proliferating mesenchymal cells. TUNEL assay demonstrated that amikacin-induced fin defects might not associate with apoptosis. Therefore, further investigations are required to elucidate if other cell death pathways are involved in amikacin-induced fin defects. |
| 關鍵字 | Amikacin;fin;zebrafish;ototoxicity;neuromast |
| 語言 | en |
| ISSN | 1537-6516 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Chen, Yau-Hung |
| 審稿制度 | 否 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/76971 ) |