Synthesis of 2‐(pyridylvinyl)chromen‐4‐ones and their N‐oxide analogs for assessment of their biological activities as anticancer agents
學年 112
學期 2
出版（發表）日期 2024-04-01
作品名稱 Synthesis of 2‐(pyridylvinyl)chromen‐4‐ones and their N‐oxide analogs for assessment of their biological activities as anticancer agents
作品名稱（其他語言）
著者 Yu Chun Ding; Yi‐Cheng Chu; Chuan‐Hsin Chang; Jia‐Hua Liang; Jih‐Jung Chen; Tzenge‐Lien Shih
單位
出版者
著錄名稱、卷期、頁數 Arch. Pharm. 357(4)
摘要 2-Styrylchromones have been shown to possess a broad spectrum of biological activities. Replacing the carbon atom in 2-styrylchromones with a nitrogen atom in the benzene rings forms 2-(pyridylvinyl)chromen-4-ones (aza-2-styrylchromones). We have synthesized a series of novel 2-(pyridylvinyl)chromen-4-ones and their pyridine N-oxides to evaluate them as potential anticancer agents against human non-small-cell lung cancer cells (A549). Among the 18 synthesized molecules, compounds 18 and 8a exhibited comparable inhibitory effects to 5-fluorouracil and showed no toxicity against normal cells.
關鍵字 aza‐2‐styrylchromones;human non‐small‐cell lung cancer cells;pyridine N‐oxides.
語言 en
ISSN 1521-4184; 0365-6233
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 施增廉
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
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