Enhanced mechanical and biocompatible properties of strontium ions doped mesoporous bioactive glass
學年 109
學期 1
出版（發表）日期 2020-09-01
作品名稱 Enhanced mechanical and biocompatible properties of strontium ions doped mesoporous bioactive glass
作品名稱（其他語言）
著者 S. Amudha; J. Ramana Ramya; K. Thanigai Arul; A. Deepika; P. Sathiamurthi; B. Mohana; K. Asokan; Chung-Li Dong; S. Narayana Kalkura
單位
出版者
著錄名稱、卷期、頁數 Composites Part B: Engineering 196, 108099
摘要 Very low (≤0.2%) strontium (Sr) ion doped mesoporous (45S5) bioactive glasses (BG) were synthesized by sol-gel technique and calcination without using polymers (porogens), mould or other additives. The phases and their functional groups were confirmed by the X-ray diffraction (XRD) and Fourier transform infrared (FTIR) and FT-Raman spectroscopy respectively. Sodium calcium phosphate silicate [(Na0.11Ca0.89) (P0.11Si0.89O3)] which is essential for assisting the self-repair process of enamel was formed along with sodium calcium silicate (Na2Ca2Si3O9) phase. Doping of Sr ions (0.2 wt %) enhances the pore volume (96%) and surface area (108%) compared to pristine. Further, interconnected network structures are created exhibiting controlled and sustained drug release (58% in 720 h). The mechanical strength of the Sr doped BG samples increased significantly. The compressive strength of sample (Sr = 0.2 and 0.5 wt %) were 8.1 ± 0.5 and 11.2 ± 0.5 MPa with respective percentage increase of 440 and 647% compared to BG. The thermal stability and zeta potential of the Sr doped BG samples increase with considerable variation in the particle size when compared to the pristine. The cell viability and proliferation were also significantly enhanced by the doping of Sr ions which tailor the surface properties as well. The overall results robustly demonstrate for the first time that the very low doping of Sr ions (≤0.2%) in BG, play a major role in engineering the properties viz., mechanical, surface, drug release and cell proliferation making them suitable for multifunctional biomedical applications.
關鍵字 Bioglass;Raman spectroscopy;Sustained drug release;Bioactivity
語言 en_US
ISSN 1879-1069
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
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