Raman Spectroscopic Analysis of Cataract Lens: A Compendious Review
學年 106
學期 1
出版（發表）日期 2018-01-03
作品名稱 Raman Spectroscopic Analysis of Cataract Lens: A Compendious Review
作品名稱（其他語言）
著者 Chia-Chi Huang; Wenlung Chen
單位
出版者
著錄名稱、卷期、頁數 Applied Spectroscopy Reviews 53(9), P.689-702
摘要 Age-related cataracts is a pressing health issue with the increase in elderly populations. This creates an imminent demand for the development of an early, noninvasive method of cataracts diagnosis. Early detection of cataracts will improve quality of life and may prevent morbidity associated with advanced cataracts and surgery. Raman spectrum of proteins provides characteristic information regarding molecular interactions of peptide residues. Hence Raman spectroscopy is a promising tool for the study of protein-related diseases, such as cataracts. We surveyed the literature to assess the use of Raman technology in the studies of human lens and animal models. These studies included analysis of amino acids (i.e., cysteine, tryptophan, and tyrosine, etc.) and secondary protein structures (i.e., α-helix and β-sheet) in various Raman profiles. Other studies used Raman spectroscopy to analyze and monitor the development of cataracts in lens. Technological advances in the instrumentation of laser Raman spectroscopy, including Fourier transform Raman spectroscopy, Raman microspectroscopy, and confocal Raman microspectroscopy have improved the performance of Raman spectroscopic analysis. How to take advantage of these developments and make it closer to reality using Raman spectroscopic methods to diagnose cataracts in a timely manner is a key challenge for the scientific community of Raman spectroscopy.
關鍵字 Cataract;lens;Raman spectroscopy;amino acids;secondary structures of protein
語言 en_US
ISSN 1520-569X
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 TWN
公開徵稿
出版型式 ,電子版
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