教師資料查詢 | 類別: 期刊論文 | 教師: 蔡志群 Chih-chun Tsai (瀏覽個人網頁)

標題:Effects of Poor Hepatic Reserve in Cirrhotic Patients with Bacterial Infections: A Population‑based Study
學年107
學期2
出版(發表)日期2019/02/18
作品名稱Effects of Poor Hepatic Reserve in Cirrhotic Patients with Bacterial Infections: A Population‑based Study
作品名稱(其他語言)
著者Tsung-Hsing Hung; Chih-Chun Tsai; Hsing-Feng Leea
單位
出版者
著錄名稱、卷期、頁數Tzu Chi Medical Journal 32(1), p.47-52
摘要Objective: Ascites, hepatic encephalopathy, hepatorenal syndrome, spontaneous bacterial peritonitis, and esophageal variceal bleeding are major complications associated with cirrhosis. The presence of these complications indicates poor hepatic reserve. This study aimed to identify the effects of poor hepatic reserve on mortality in cirrhotic patients with bacterial infections.
Patients and methods: The Taiwan National Health Insurance Database was used to identify 43,042 cirrhotic patients with bacterial infections hospitalized between January 1, 2010, and December 31, 2013, after propensity score matching analysis. Of these, 21,521 cirrhotic patients had major cirrhotic-related complications and were considered to have poor hepatic reserve.
Results: Mortality rates at 30 and 90 days were 24.2% and 39.5% in the poor hepatic reserve group and 12.8% and 21.7% in the good hepatic reserve group, respectively (P < 0.001 for each group). The cirrhotic patients with poor hepatic reserve (hazard ratio [HR], 2.10; 95% confidence interval [CI] = 2.03-2.18; P < 0.001) had significantly increased mortality at 90 days. The mortality HRs in patients with one, two, and three or more complications compared to patients without complications were 1.92 (95% CI = 1.85-1.99, P < 0.001), 2.61 (95% CI = 2.47-2.77, P < 0.001), and 3.81 (95% CI = 3.18-4.57, P < 0.001), respectively.
Conclusion: In cirrhotic patients with bacterial infections, poor hepatic reserve is associated with a poor prognosis. The presence of three or more cirrhotic-related complications increases mortality almost four folds.
關鍵字Bacterial infections;Complications;Liver cirrhosis
語言英文
ISSN
期刊性質國內
收錄於ESCI;
產學合作
通訊作者
審稿制度
國別中華民國
公開徵稿
出版型式,電子版
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