教師資料查詢 | 類別: 期刊論文 | 教師: 謝璦如 HSIEH, AI-RU (瀏覽個人網頁)

標題:Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy
學年108
學期1
出版(發表)日期2020/01/24
作品名稱Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy
作品名稱(其他語言)
著者Hsieh Ai-Ru(謝璦如); Yu-Chuen Huang; Hui-Ju Lin; Ya-Wen Chang; Chia-Ming Wu; Wen-Ling Liao; Fuu-Jen Tsai
單位
出版者
著錄名稱、卷期、頁數BMJ Open Diabetes Research & Care 8(1)
摘要Objective Diabetic nephropathy (DN) and diabetic
retinopathy (DR) comprise major microvascular
complications of diabetes that occur with a high
concordance rate in patients and are considered to
potentially share pathogeneses. In this case-control
study, we sought to investigate whether DR-related single
nucleotide polymorphisms (SNPs) exert pleiotropic effects
on renal function outcomes among patients with diabetes.
Research design and methods A total of 33 DR-related
SNPs were identified by replicating published SNPs and
via a genome-wide association study. Furthermore, we
assessed the cumulative effects by creating a weighted
genetic risk score and evaluated the discriminatory and
prediction ability of these genetic variants using DN cases
according to estimated glomerular filtration rate (eGFR)
status along with a cohort with early renal functional
decline (ERFD).
Results Multivariate logistic regression models revealed
that the DR-related SNPs afforded no individual or
cumulative genetic effect on the nephropathy risk, eGFR
status or ERFD outcome among patients with type two
diabetes in Taiwan.
Conclusion Our findings indicate that larger studies would
be necessary to clearly ascertain the effects of individual
genetic variants and further investigation is also required
to identify other genetic pathways underlying DN.
關鍵字diabetic nephropathy;diabetic retinopathy;pleiotropic effect
語言英文(美國)
ISSN2052-4897
期刊性質國外
收錄於SCI;
產學合作
通訊作者
審稿制度
國別英國
公開徵稿
出版型式,電子版
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