教師資料查詢 | 類別: 期刊論文 | 教師: 溫啟仲 WEN,CHI-CHUNG (瀏覽個人網頁)

標題:Sample size determination for semiparametric analysis of current status data
學年108
學期1
出版(發表)日期2019/08/01
作品名稱Sample size determination for semiparametric analysis of current status data
作品名稱(其他語言)
著者Wen CC; Chen YH
單位
出版者
著錄名稱、卷期、頁數Statistical Methods in Medical Research 28, p.2247-2257
摘要Semiparametric transformation models, which include the Cox proportional hazards and proportional odds models as special cases, are popular in current practice of survival analysis owing to that, in contrast to parametric models, no assumption on the baseline distribution is required. Although sample size calculations for semiparametric survival analysis with right-censored data are available, no such calculation exits in literature for semiparametric analysis with current status data, where only an examination time and whether the event occurs prior to the examination are observable. We develop sample size calculation for semiparametric two-group comparison or regression analysis with current status data. The proposed formula can be readily implemented with given effect size, power level, covariate group proportions, covariate-specific examination (censoring) time distributions, and proportions of events observed in the control group at a few knot points in the study period. Simulation results show that the proposed sample size calculation is adequate in the sense that it leads to studies with empirical power very close to the planned power level. We illustrate practical applications of the proposal through examples from an animal tumorigenicity study and a cross-sectional survey on osteoporosis status in the elderly.
關鍵字Cox proportional hazards model;power;sample size calculation;study design;transformation models
語言英文
ISSN0962-2802
期刊性質國外
收錄於SCI;
產學合作
通訊作者
審稿制度
國別英國
公開徵稿
出版型式,電子版
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