教師資料查詢 | 類別: 期刊論文 | 教師: 王三郎 WANG SAN-LANG (瀏覽個人網頁)

標題:Anti-Oxidant and Anti-Diabetes Potential of Water-Soluble Chitosan–Glucose Derivatives Produced by Maillard Reaction
學年108
學期1
出版(發表)日期2019/10/18
作品名稱Anti-Oxidant and Anti-Diabetes Potential of Water-Soluble Chitosan–Glucose Derivatives Produced by Maillard Reaction
作品名稱(其他語言)
著者Tran TN; Doan CT; Nguyen VB; Nguyen AD; Wang SL
單位
出版者
著錄名稱、卷期、頁數Polymers 11(10), 1714
摘要Chitosan-sugar derivatives demonstrate some useful biology activities (for example antioxidant and anti-microbial activities). In this study, water-soluble chitosan–glucose derivatives
(WSCGDs) were produced from a water-soluble chitosan hydrochloride (WSC) with 12.5 kDa of
molecular weight and 24.05% of degree of acetylation (DA) via Maillard reaction with the heating
temperatures of 100 °C and 121 °C. The Maillard reaction between WSC and glucose was
investigated by measuring the absorbances at 420 nm and 294 nm, indicating that the reaction took
place more effectively at 121 °C. All WSCGDs exhibited higher anti-oxidant activity than WSC, in
which WSCGDs obtained at the treatment 121 °C for 2 h, 3 h, and 4 h expressed the highest ability
(IC50 range from 1.90–1.05 mg/mL). Increased anti-α-amylase and anti-α-glucosidase activities were
also observed in WSCGDs from the treatment at 121 °C. In detail, the highest IC50 values of anti-αamylase activity were 18.02 mg/mL (121 °C, 3 h) and 18.37 mg/mL (121 °C, 4 h), whereas the highest
IC50 values of anti-α-glucosidase activity were in range of 7.09–5.72 mg/mL (121 °C, for 1–4 h).
According to the results, WSCGD obtained from 121 °C for 3 h was selected for further
characterizing by high performance liquid chromatography size exclusion chromatography (HPLC
SEC), colloid titration, FTIR, as well as 1H-NMR, indicating that the derivative of WSC and glucose
was successfully synthesized with a molecular weight of 15.1 kDa and degree of substitution (DS)
of 34.62 ± 2.78%. By expressing the excellent anti-oxidant and anti-diabetes activities, WSCGDs may
have potential use in health food or medicine applications.
關鍵字chitosan–glucose derivatives;Maillard reaction;anti-oxidant;anti-α-amylase;anti-αglucosidase;anti-diabetes
語言英文
ISSN2073-4360
期刊性質國外
收錄於SCI;
產學合作
通訊作者San-Lang Wang
審稿制度
國別瑞士
公開徵稿
出版型式,電子版
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