教師資料查詢 | 類別: 期刊論文 | 教師: 王三郎 WANG SAN-LANG (瀏覽個人網頁)

標題:New indications of potential rat intestinal α-glucosidase inhibition by Syzygium zeylanicum (L.) and its hypoglycemic effect in mice
學年108
學期1
出版(發表)日期2019/10/15
作品名稱New indications of potential rat intestinal α-glucosidase inhibition by Syzygium zeylanicum (L.) and its hypoglycemic effect in mice
作品名稱(其他語言)
著者Van Bon Nguyen; San-Lang Wang; Thi Hanh Nguyen; Chien Thang Doan; Thi Ngoc Tran; Yao-Haur Kuo; Quang Vinh Nguyen; Anh Dzung Nguyen
單位
出版者
著錄名稱、卷期、頁數Research on Chemical Intermediates
摘要Natural α-glucosidase inhibitors (aGIs) have been considered efective agents for type 2 diabetes management. In this study, Syzygium zeylanicum (L.) (SZL), a medicinal plant that grows wild in the Central Highlands of Vietnam, was reported for the frst time to have potential anti-diabetic properties. The methanol extract of SZL possessed potent rat intestinal α-glucosidase inhibitory activity with low IC50
and great maximum inhibition values of 109 µg/mL and 100%, respectively. This was higher activity than acarbose, an anti-diabetic drug with IC50 and maximum inhibition values of 540 µg/ml and 80%, respectively. In specifc inhibition tests, the herbal extract demonstrated strong inhibition against α-glucosidases from Saccharomyces cerevisiae and Bacillus stearothermophilus with small IC50 values of
0.18 and 0.31 µg/mL, respectively. SZL extract also demonstrated potent inhibition against porcine pancreatic α-amylase with maximum inhibition and IC50 values of 99.2% and 3.7 µg/mL, respectively. SZL displayed high thermal and pH stability,
with respective activities of 87% and 100–140% when treated at 100 °C or over a wide pH range of 2–13. The herbal extract was further investigated for its efcacy
using ICR mice as the animal model. At a dose of 100 mg/kg BW, SZL signifcantly reduced blood glucose in mice and no signs of diarrhea were observed. The results from this study suggest that SZL, a potent and natural source of aGIs, may be a good candidate for the treatment of type 2 diabetes.
關鍵字α-Glucosidase inhibitors;Diabetes;Syzygium zeylanicum (L.);Hypoglycemic efect
語言英文
ISSN0922-6168
期刊性質國外
收錄於SCI;
產學合作
通訊作者San-Lang Wang
審稿制度
國別美國
公開徵稿
出版型式,電子版
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