教師資料查詢 | 類別: 期刊論文 | 教師: 謝璦如 HSIEH, AI-RU (瀏覽個人網頁)

標題:Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma
學年105
學期2
出版(發表)日期2017/02/07
作品名稱Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma
作品名稱(其他語言)
著者Hsieh Ai-Ru; Chu CM; Yeh CT; Lin HG; Wan SY; Chen YC; Hsu CL; Lin SM; Fann Cathy SJ; Dar-In Tai
單位
出版者
著錄名稱、卷期、頁數World Journal of Gastroenterology 23(5), p.876-884
摘要AIM
To explore factors associated with persistent hepatitis B virus (HBV) infection in a cohort of hepatocellular carcinoma (HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen (HBsAg)-positive relatives.

METHODS
We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structured questionnaire. Demographics, relationship to index case, HBsAg status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis.

RESULTS
Among 729 relatives enrolled, parent generation (P = 0.0076), index generation (P = 0.0044), mothers positive for HBsAg (P = 0.0007), and HBsAg-positive index cases (P = 5.98 × 10-8) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBsAg-positive relatives. Parent generation (P = 0.0359) and sex (P = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBsAg-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46 (58.7%) families. Male offspring of HBsAg-positive mothers (P = 0.024) and older siblings were associated with high viral load.

CONCLUSION
Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations.
關鍵字Familial generation;Sex;Hepatitis B virus;Perinatal infection;Viral replication
語言中文
ISSN
期刊性質國內
收錄於
產學合作
通訊作者
審稿制度
國別中華民國
公開徵稿
出版型式,電子版
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