教師資料查詢 | 類別: 期刊論文 | 教師: 謝璦如 HSIEH, AI-RU (瀏覽個人網頁)

標題:Association of plasma thrombospondin-1 level with cardiovascular disease and mortality in hemodialysis patients
學年103
學期2
出版(發表)日期2015/05/01
作品名稱Association of plasma thrombospondin-1 level with cardiovascular disease and mortality in hemodialysis patients
作品名稱(其他語言)
著者Chi-Lun Huang; Yuh-Shiun Jong; Yen-Wen Wu; Wei-Jie Wang; Hsieh Ai-Ru; Chia-Lun Chao; Wen-Jone Chen; Wei-Shiung Yang
單位
出版者
著錄名稱、卷期、頁數Acta Cardiologica Sinica 31(2), p.113-119
摘要Background
Thrombospondin-1 (TSP-1) is known to be involved in the regulation of angiogenesis, inflammation, and vascular function. Clinical studies have demonstrated its correlation with peripheral artery disease, coronary artery disease, and pulmonary hypertension. In this study, we explored its potential roles in the background of end-stage renal disease (ESRD).

Methods
A total of 140 ESRD outpatients (ages 61.0 ± 12.4 years) were prospectively followed for 34 ± 7 months. Their TSP-1 levels were analyzed from pre-hemodialysis blood sample. Cardiovascular survey included ankle- brachial index (ABI), echocardiography and Tl-201 dipyridamole single-photon emission computed tomography (SPECT).

Results
Plasma TSP-1 levels were higher in those patients with preexisting clinical evidence of cardiovascular disease (CVD) than those without (p = 0.002). TSP-1 concentrations were also correlated with ABI, left ventricular ejection fraction, and scar burden in SPECT. Stepwise logistic regression analysis revealed that TSP-1 level was independently associated with the presence of CVD, with an odds ratio of 1.38 [95% confidence interval (CI), 1.09-1.75, p = 0.008]. In survival analyses, 31 patients (22%) died during the follow-up, 16 (52%) arising from cardiovascular causes. Cox hazards analysis revealed that the patients with TSP-1 levels in the highest tertile had a 5.32- and 6.75-fold higher risk for all-cause and cardiovascular mortality than those in the lowest tertile. This predictive value for all-cause mortality still persisted after multivariate adjustment (hazard ratio, 8.71; 95% CI, 1.36-55.68; p = 0.02).

Conclusions
This study hallmarks the association of elevated TSP-1 level with CVD and adverse outcome among hemodialysis patients.
關鍵字Thrombospondin-1;End-stage renal disease;Cardiovascular disease;Mortality
語言中文
ISSN
期刊性質國內
收錄於
產學合作
通訊作者
審稿制度
國別中華民國
公開徵稿
出版型式,電子版
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