|標題：Effect of Proton Pump Inhibitors on Mortality of Cirrhotic Patients with Pneumonia|
|作品名稱||Effect of Proton Pump Inhibitors on Mortality of Cirrhotic Patients with Pneumonia|
|著者||Tsung-Hsing Hung; Chih -Wei Tseng; Chih-Chun Tsai; Hsing-Feng Lee|
|著錄名稱、卷期、頁數||PLoS One 14(4), e0216041|
Pneumonia is life-threatening in patients with liver cirrhosis. Proton pump inhibitors (PPIs)
may increase the risk of these patients developing pneumonia. However, whether PPIs
increase mortality in patients with cirrhosis and pneumonia remain unknown.
We used the Taiwan National Health Insurance Database to enroll 1,201 cirrhotic patients
with pneumonia without active gastrointestinal bleeding who were receiving PPIs and were
hospitalized between January 1, 2010 and December 31, 2013. A one-to-three propensity
score match was performed to select a comparison group based on age, gender, and
The overall 30-day and 90-day all-cause mortality rates were 13.7% and 26.9% in the PPI
group, and 14.3% and 25.1% in the non-PPI group, respectively. After Cox regression
model adjusting for age, gender, and comorbid disorders, the hazard ratios of the effect of
PPIs on 30-day and 30 to 90-day mortality were 0.94 (95% Confidence Interval [CI], 0.79–
1.12, P = 0.468) and 1.26 (95% CI, 1.05–1.52; P = 0.013), respectively.
PPIs were not associated with 30-day mortality among cirrhotic patients with pneumonia but
not active gastrointestinal bleeding. However, prolonged PPI therapy may be associated
with higher mortality.