教師資料查詢 | 類別: 期刊論文 | 教師: 蔡志群 Chih-chun Tsai (瀏覽個人網頁)

標題:Statin Use in Cirrhotic Patients with Infectious Diseases: A Population-based Study
學年107
學期2
出版(發表)日期2019/04/24
作品名稱Statin Use in Cirrhotic Patients with Infectious Diseases: A Population-based Study
作品名稱(其他語言)
著者Tsung-Hsing Hung; Chih-Chun Tsai; Hsing-Feng Lee
單位
出版者
著錄名稱、卷期、頁數PLoS One 14(4), e0215839
摘要Background
Recent studies have shown benefits of statins in patients with liver cirrhosis. However, it is
still unknown if statins have a beneficial effect on the mortality of cirrhotic patients with bacterial infections.
Methods
The Taiwan National Health Insurance Database was searched, and 816 cirrhotic patients
receiving statins with bacterial infections hospitalized between January 1, 2010 and December 31, 2013 were included in the study. A one-to-four propensity score matching was performed to select a comparison group based on age, sex, and comorbid disorders.
Results
The overall 30-day mortalities in statin and non-statin group were 5.3% and 9.8%, respectively (P = 0.001). After Cox regression modeling adjusting for age, sex, and comorbid disorders, the hazard ratio (HR) of statin use on 30-day mortality was 0.52 (95% confidence
interval [CI]: 0.38–0.72, P<0.001). In subgroup analysis, the 30-day mortality effect of statin
use was more pronounced in patients with pneumonia (HR = 0.34; 95% CI: 0.19–0.59;
P<0.001) and bacteremia (HR = 0.55; 95% CI: 0.35–0.85; P = 0.008). Atovastatin (HR =
0.59; 95% CI: 0.37–0.93) and rosuvastatin (HR = 0.59; 95% CI: 0.36–0.98) were associated
with a decreased 30-day mortality risk compared to patients not taking statins.
Conclusions
Statin use decreases the 30-day mortality of cirrhotic patients with bacteremia and
pneumonia.
關鍵字
語言英文
ISSN1932-6203
期刊性質國外
收錄於SCI;
產學合作
通訊作者
審稿制度
國別美國
公開徵稿
出版型式,電子版
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