教師資料查詢 | 類別: 期刊論文 | 教師: 張玉坤 Yue-cune Chang (瀏覽個人網頁)

標題:Autism Associated with Anti-NMDAR: Encephalitis Glutamate-Related Therapy
學年107
學期2
出版(發表)日期2019/06/21
作品名稱Autism Associated with Anti-NMDAR: Encephalitis Glutamate-Related Therapy
作品名稱(其他語言)
著者Ruu-Fen Tzang; Chuan-Hsin Chang; Yue-Cune Chang; Hsien-Yuan Lane
單位
出版者
著錄名稱、卷期、頁數Frontiers in Psychiatry 10, p.440
摘要The purpose of this review is to correlate autism with autoimmune dysfunction in the absence
of an explanation for the etiology of autism spectrum disorder. The anti-N-methyl-Daspartate
receptor (anti-NMDAR) autoantibody is a typical synaptic protein that can bind to
synaptic NMDA glutamate receptors, leading to dysfunctional glutamate neurotransmission
in the brain that manifests as psychiatric symptoms (psychosis, hallucinations, and
personality changes). Detection of autoantibodies, cytokines, decreased lymphocytes,
serum immunoglobulin level imbalance, T-cell mediated immune profile, maternal infection
history, and children’s infection history can all be vital biological markers of autoimmune
autism. Diagnosing autoimmune encephalitis sooner can increase the effectiveness of
curative treatments—such as immune therapy or immune modulatory therapy—that may
prevent the long-term consequence of being misdiagnosed with autism spectrum disorder.
Glutamate therapy primarily normalizes glutamate neurotransmission and can be a new
add-on intervention alongside antipsychotics for treating autoimmune autism.
關鍵字autoimmune autism;glutamate-related therapy;anti-N-methyl-D-aspartate receptor encephalitis;immune therapy;dysfunctional glutamate neurotransmission
語言英文(美國)
ISSN
期刊性質國外
收錄於SCI;
產學合作
通訊作者Hsien-Yuan Lane
審稿制度
國別美國
公開徵稿
出版型式,電子版
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